Beyond the Connectome: The Dynome
نویسندگان
چکیده
The human connectome will provide a detailed mapping of the brain's connectivity, with fundamental insights for health and disease. However, further understanding of brain function and dysfunction will require an integrated framework that links brain connectivity with brain dynamics, as well as the biological details that relate this connectivity more directly to function. In this Perspective, we describe such a framework for studying the brain's "dynome" and its relationship to cognition.
منابع مشابه
Mapping Circuits beyond the Models: Integrating Connectomics and Comparative Neuroscience
The brain has been shaped by evolution, and its connectome reflects that history. Comparative neuroscience research, framed by evolutionary relationships, is key to interpreting connectome organization and can address fundamental circuit questions that are not accessible through single-species connectomics efforts.
متن کاملNetwork centrality in the human functional connectome.
The network architecture of functional connectivity within the human brain connectome is poorly understood at the voxel level. Here, using resting state functional magnetic resonance imaging data from 1003 healthy adults, we investigate a broad array of network centrality measures to provide novel insights into connectivity within the whole-brain functional network (i.e., the functional connect...
متن کاملCommentary on: Labels, cognomes, and cyclic computation: an ethological perspective
A commentary on Labels, cognomes and cyclic computation: an ethological perspective by Murphy, E. Murphy (2015) seeks to gain insight into the phylogeny of the human language faculty by adopting a computational perspective. After surveying the ethology literature in an attempt to isolate what is lacking in other species at the computational level, Murphy claims that the process of Labeling, wel...
متن کاملThe gut connectome: making sense of what you eat.
The enteric nervous system has been studied thus far as an isolated unit. As researchers probe deeper into the function of this system, it is evident that the neural network stretches beyond enteric neurons. It is formed by both intrinsic and extrinsic neurons innervating the gut, enteric glia, and innervated sensory epithelial cells, such as enteroendocrine cells. This Review series summarizes...
متن کاملThe structural connectome of the human brain in agenesis of the corpus callosum
Adopting a network perspective, the structural connectome reveals the large-scale white matter connectivity of the human brain, yielding insights into cerebral organization otherwise inaccessible to researchers and clinicians. Connectomics has great potential for elucidating abnormal connectivity in congenital brain malformations, especially axonal pathfinding disorders. Agenesis of the corpus ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Neuron
دوره 83 شماره
صفحات -
تاریخ انتشار 2014